Granulocyte Macrophage Colony-Stimulating Factor-Specific Autoantibodies and Cerebral Nocardia With Pulmonary Alveolar Proteinosis | Zendy

Charlotte Berthoux | Zendy; Morgane Mailhe | Zendy; Fréderic Vely | Zendy; Clarisse Gauthier | Zendy; JeanLouis Mège | Zendy; JeanChristophe Lagier | Zendy; Cléa Melenotte | Zendy

Open Access

Granulocyte Macrophage Colony-Stimulating Factor-Specific Autoantibodies and Cerebral Nocardia With Pulmonary Alveolar Proteinosis

Author(s) -

Charlotte Berthoux,

Morgane Mailhe,

Fréderic Vely,

Clarisse Gauthier,

JeanLouis Mège,

JeanChristophe Lagier,

Cléa Melenotte

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa612

Subject(s) - medicine , pulmonary alveolar proteinosis , granulocyte macrophage colony stimulating factor , nocardia , autoantibody , asymptomatic , immunology , pathology , granulocyte , alveolar macrophage , brain abscess , macrophage , lung , abscess , antibody , cytokine , surgery , biology , biochemistry , bacteria , in vitro , genetics

In this study, we report the history of a 40-year-old man with a primary cerebral abscess caused by Nocardia abscessus that led to the discovery of autoimmune pulmonary alveolar lipoproteinosis (anti-granulocyte-macrophage colony-stimulating factor [GM-CSF] autoantibodies). Anti-GM-CSF autoantibodies promote immunodeficiency and should be monitored to prevent opportunistic and disseminated infections and to diagnose asymptomatic pulmonary alveolar lipoproteinosis.

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