Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions | Zendy

Ben J. Marais | Zendy; Elaine Cheong | Zendy; Shelanah Fernando | Zendy; Santhosh Daniel | Zendy; Matthew Watts | Zendy; Lucinda J. Berglund | Zendy; Simone Barry | Zendy; George Kotsiou | Zendy; Alex P. Headley | Zendy; Richard Stapledon | Zendy

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Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions

Author(s) -

Ben J. Marais,

Elaine Cheong,

Shelanah Fernando,

Santhosh Daniel,

Matthew Watts,

Lucinda J. Berglund,

Simone Barry,

George Kotsiou,

Alex P. Headley,

Richard Stapledon

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa604

Subject(s) - infliximab , medicine , paradoxical reaction , tuberculous meningitis , meningitis , tuberculosis , intensive care medicine , surgery , tumor necrosis factor alpha , pathology

We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes.

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