Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement | Zendy

Shanti Narayanasamy | Zendy; Roger L. Nation | Zendy; Andrew A. Mahony | Zendy; M. Lindsay Grayson | Zendy; Jason C. Kwong | Zendy; Norelle L. Sherry | Zendy; Sharmila Khumra | Zendy; Andrew G. Ellis | Zendy; Albert G. Frauman | Zendy; Natasha E. Holmes | Zendy

Open Access

Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement

Author(s) -

Shanti Narayanasamy,

Roger L. Nation,

Andrew A. Mahony,

M. Lindsay Grayson,

Jason C. Kwong,

Norelle L. Sherry,

Sharmila Khumra,

Andrew G. Ellis,

Albert G. Frauman,

Natasha E. Holmes

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa572

Subject(s) - medicine , colistin , pseudomonas aeruginosa , fosfomycin , debridement (dental) , osteomyelitis , drug , surgery , antibiotics , pharmacology , microbiology and biotechnology , bacteria , biology , genetics

We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity.

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