HBcAb Positivity Increases the Risk of Severe Hepatic Fibrosis Development in HIV/HCV-Positive Subjects From the ICONA Italian Cohort of HIV-Infected Patients | Zendy

Vincenzo Malagnino | Zendy; Carlotta Cerva | Zendy; Antonella Cingolani | Zendy; Francesca CeccheriniSilberstein | Zendy; Alessandra Vergori | Zendy; Gianluca Cuomo | Zendy; Carlo Federico Perno | Zendy; Massimo Puoti | Zendy; Antonella d’Arminio Monforte | Zendy; Alessandro CozziLepri | Zendy; Massimo Andreoni | Zendy; Loredana Sarmati | Zendy; Andrea Antinori | Zendy; Antonella Castagna | Zendy; Francesco Castelli | Zendy; Roberto Cauda | Zendy; Giovanni Di Perri | Zendy; Massimo Galli | Zendy; Rosaria Iardino | Zendy; Giuseppe Ippolito | Zendy; Adriano Lazzarin | Zendy; Giulia Marchetti | Zendy; G Rezza | Zendy; F von Schloesser | Zendy; P. Viale | Zendy; Enrico Girardi | Zendy; Andrea Gori | Zendy; Sergio Lo Caputo | Zendy; Franco Maggiolo | Zendy; C Mussini | Zendy; Francesca Bai | Zendy; Alessandra Bandera | Zendy; Stefano Bonora | Zendy; Marco Borderi | Zendy; Andrea Calcagno | Zendy; Maria Rosaria Capobianchi | Zendy; S Cicalini | Zendy; Paola Cinque | Zendy; Antonio Di Biagio | Zendy; Roberta Gagliardini | Zendy; Nicola Gianotti | Zendy; G Guaraldi | Zendy; Giuseppe Lapadula | Zendy; Miriam Lichtner | Zendy; Alessia Lai | Zendy; Giordano Madeddu | Zendy; Esther Merlini | Zendy; Silvia Nozza | Zendy; Stefania Piconi | Zendy; Carmela Pinnetti | Zendy; Eugenia Quirós-Roldán | Zendy; Roberto Rossotti | Zendy; Stefano Rusconi | Zendy; Maria Mercedes Santoro | Zendy; Annalisa Saracino | Zendy; Vincenzo Spagnuolo | Zendy; Valentina Svicher | Zendy; Lucia Taramasso | Zendy; Iuri Fanti | Zendy; Laura Galli | Zendy; Patrizia Lorenzini | Zendy; A Rodano’ | Zendy; Marco Macchia | Zendy; A Tavelli | Zendy; Albert Bové | Zendy; A. Camposeragna | Zendy; Massimiliano Errico | Zendy; Marco Manfredini | Zendy; A Perziano | Zendy; Valeria Calvino | Zendy; Fabrizio Carletti | Zendy; Silvia Carrara | Zendy; Antonino Di | Zendy; Silvia Graziano | Zendy; F Petroni | Zendy; Gennaro Prota | Zendy; S Truffa | Zendy; Andrea Giacometti | Zendy; Andrea Costantini | Zendy; V Barocci | Zendy; Gioacchino Angarano | Zendy; Laura Monno | Zendy; Eugenio Milano | Zendy; Claudia Suardi | Zendy; Valentina Donati | Zendy; G Verucchi | Zendy; Filippo Castelnuovo | Zendy; C Minardi | Zendy; Barbara Menzaghi | Zendy; C Abeli | Zendy; Luchino Chessa | Zendy; Francesco Pes | Zendy; Bruno Cacopardo | Zendy; Benedetto Maurizio Celesia | Zendy; Jacopo Vecchiet | Zendy; Katia Falasca | Zendy; Angelo Pan | Zendy; Silvia Lorenzotti | Zendy; L Sighinolfi | Zendy; Daniela Segala | Zendy; P. Blanc | Zendy; Francesca Vichi | Zendy; Giovanni Cassola | Zendy; Matteo Bassetti | Zendy; A. Alessandrini | Zendy; Nicoletta Bobbio | Zendy; Giovanni Mazzarello | Zendy; Laura Fondaco | Zendy; Paolo Bonfanti | Zendy; Chiara Molteni | Zendy; Alessandro Chiodera | Zendy; P Milini | Zendy; Giuseppe Nunnari | Zendy; Giovanni Francesco Pellicanò | Zendy; Gloria Montenegro Rizzardini | Zendy; Elvira Stefania Cannizzo | Zendy; M C Moioli | Zendy; R. Piolini | Zendy; Dario Bernacchia | Zendy; Andrea Poli | Zendy; Camilla Tincati | Zendy; Cinzia Puzzolante | Zendy; C Migliorino | Zendy; Vincenzo Sangiovanni | Zendy; Guglielmo Borgia | Zendy; Vincenzo Esposito | Zendy; G Di Flumeri | Zendy; Ivan Gentile | Zendy; Vincent Rizzo | Zendy; Anna Maria Cattelan | Zendy; Serena Marinello | Zendy; Antonio Cascio | Zendy; Marcello Trizzino | Zendy; Daniela Francisci | Zendy; Elisabetta Schiaroli | Zendy; Giustino Parruti | Zendy; F Sozio | Zendy; C Lazzaretti | Zendy; R Corsini | Zendy; Antonio Cristaudo | Zendy; Vincenzo Vullo | Zendy; R Acinapura | Zendy; Silvia Lamonica | Zendy; M Capozzi | Zendy; Annalisa Mondi | Zendy; Marco Rivano Capparuccia | Zendy; Giancarlo Iaiani | Zendy; Alessandra Latini | Zendy; Giovanna Onnelli | Zendy; Maria Maddalena Plazzi | Zendy; Giovanni de Girolamo | Zendy; M Cecchetto | Zendy; Franco Viviani | Zendy; Andrea De Vito | Zendy; Barbara Rossetti | Zendy; Francesca Montagnani | Zendy; Antonina Franco | Zendy; Rosario Vecchio | Zendy; Giuliano Enzi | Zendy; P Caramello | Zendy; Giancarlo Orofino | Zendy; Mariangela Sciandra | Zendy; AP Londero | Zendy; Vinicio Manfrin | Zendy; Giuliana Battagin | Zendy; Giulio Starnini | Zendy; A Ialungo | Zendy

Open Access

HBcAb Positivity Increases the Risk of Severe Hepatic Fibrosis Development in HIV/HCV-Positive Subjects From the ICONA Italian Cohort of HIV-Infected Patients

Author(s) -

Vincenzo Malagnino,

Carlotta Cerva,

Antonella Cingolani,

Francesca CeccheriniSilberstein,

Alessandra Vergori,

Gianluca Cuomo,

Carlo Federico Perno,

Massimo Puoti,

Antonella d’Arminio Monforte,

Alessandro CozziLepri,

Massimo Andreoni,

Loredana Sarmati,

Andrea Antinori,

Antonella Castagna,

Francesco Castelli,

Roberto Cauda,

Giovanni Di Perri,

Massimo Galli,

Rosaria Iardino,

Giuseppe Ippolito,

Adriano Lazzarin,

Giulia Marchetti,

G Rezza,

F von Schloesser,

P. Viale,

Enrico Girardi,

Andrea Gori,

Sergio Lo Caputo,

Franco Maggiolo,

C Mussini,

Francesca Bai,

Alessandra Bandera,

Stefano Bonora,

Marco Borderi,

Andrea Calcagno,

Maria Rosaria Capobianchi,

S Cicalini,

Paola Cinque,

Antonio Di Biagio,

Roberta Gagliardini,

Nicola Gianotti,

G Guaraldi,

Giuseppe Lapadula,

Miriam Lichtner,

Alessia Lai,

Giordano Madeddu,

Esther Merlini,

Silvia Nozza,

Stefania Piconi,

Carmela Pinnetti,

Eugenia Quirós-Roldán,

Roberto Rossotti,

Stefano Rusconi,

Maria Mercedes Santoro,

Annalisa Saracino,

Vincenzo Spagnuolo,

Valentina Svicher,

Lucia Taramasso,

Iuri Fanti,

Laura Galli,

Patrizia Lorenzini,

A Rodano’,

Marco Macchia,

A Tavelli,

Albert Bové,

A. Camposeragna,

Massimiliano Errico,

Marco Manfredini,

A Perziano,

Valeria Calvino,

Fabrizio Carletti,

Silvia Carrara,

Antonino Di,

Silvia Graziano,

F Petroni,

Gennaro Prota,

S Truffa,

Andrea Giacometti,

Andrea Costantini,

V Barocci,

Gioacchino Angarano,

Laura Monno,

Eugenio Milano,

Claudia Suardi,

Valentina Donati,

G Verucchi,

Filippo Castelnuovo,

C Minardi,

Barbara Menzaghi,

C Abeli,

Luchino Chessa,

Francesco Pes,

Bruno Cacopardo,

Benedetto Maurizio Celesia,

Jacopo Vecchiet,

Katia Falasca,

Angelo Pan,

Silvia Lorenzotti,

L Sighinolfi,

Daniela Segala,

P. Blanc,

Francesca Vichi,

Giovanni Cassola,

Matteo Bassetti,

A. Alessandrini,

Nicoletta Bobbio,

Giovanni Mazzarello,

Laura Fondaco,

Paolo Bonfanti,

Chiara Molteni,

Alessandro Chiodera,

P Milini,

Giuseppe Nunnari,

Giovanni Francesco Pellicanò,

Gloria Montenegro Rizzardini,

Elvira Stefania Cannizzo,

M C Moioli,

R. Piolini,

Dario Bernacchia,

Andrea Poli,

Camilla Tincati,

Cinzia Puzzolante,

C Migliorino,

Vincenzo Sangiovanni,

Guglielmo Borgia,

Vincenzo Esposito,

G Di Flumeri,

Ivan Gentile,

Vincent Rizzo,

Anna Maria Cattelan,

Serena Marinello,

Antonio Cascio,

Marcello Trizzino,

Daniela Francisci,

Elisabetta Schiaroli,

Giustino Parruti,

F Sozio,

C Lazzaretti,

R Corsini,

Antonio Cristaudo,

Vincenzo Vullo,

R Acinapura,

Silvia Lamonica,

M Capozzi,

Annalisa Mondi,

Marco Rivano Capparuccia,

Giancarlo Iaiani,

Alessandra Latini,

Giovanna Onnelli,

Maria Maddalena Plazzi,

Giovanni de Girolamo,

M Cecchetto,

Franco Viviani,

Andrea De Vito,

Barbara Rossetti,

Francesca Montagnani,

Antonina Franco,

Rosario Vecchio,

Giuliano Enzi,

P Caramello,

Giancarlo Orofino,

Mariangela Sciandra,

AP Londero,

Vinicio Manfrin,

Giuliana Battagin,

Giulio Starnini,

A Ialungo

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa566

Subject(s) - medicine , human immunodeficiency virus (hiv) , cohort , hepatic fibrosis , cohort study , virology , fibrosis

Background The aim of this study was to investigate the impact of anti-HBc (HBcAb) positivity on the progression of liver fibrosis (Fibrosis-4 score >3.25) in the Italian cohort of HIV-infected individuals naïve to antiretroviral treatment (ICONA). Methods All patients with FIB-4 <3.25 at baseline were evaluated prospectively: 6966 people with HIV (PWH) were screened and classified based on hepatitis B virus (HBV) and hepatitis C virus (HCV) serology. Results Patients who were HBcAb+/HCV-/HBs antigen (HBsAg)- and HCV+/HBcAb+/HBsAg- or HBsAg+/HBcAb+/HCV- had CD4+ cell counts below the nadir and significantly higher prevalence of AIDS diagnosis at baseline than the other groups (P < .0001). A Cox regression model adjusted for age, HIV transmission mode, country of birth, and alcohol consumption showed a higher relative risk (HR) of progression to FIB-4 >3.25 in HCV+/HBcAb+/HBsAg- patients (HR, 7.2; 95% CI, 3 8–13.64). Conclusions HBcAb+ contributes to liver damage in HIV+/HCV+/HBcAb+/HBsAg- subjects. A careful monitoring for signs of previous HBV infection is needed in this kind of patients.

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