Neopterin Predicts Disease Severity in Hospitalized Patients With COVID-19 | Zendy

Rosa BellmannWeiler | Zendy; Lukas Lanser | Zendy; Francesco Burkert | Zendy; Stefanie Seiwald | Zendy; Gernot Fritsche | Zendy; Sophie Wildner | Zendy; Andrea Schroll | Zendy; Sabine Koppelstätter | Zendy; Katharina Kurz | Zendy; Andrea Griesmacher | Zendy; Günter Weiß | Zendy

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Neopterin Predicts Disease Severity in Hospitalized Patients With COVID-19

Author(s) -

Rosa BellmannWeiler,

Lukas Lanser,

Francesco Burkert,

Stefanie Seiwald,

Gernot Fritsche,

Sophie Wildner,

Andrea Schroll,

Sabine Koppelstätter,

Katharina Kurz,

Andrea Griesmacher,

Günter Weiß

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa521

Subject(s) - neopterin , medicine , intensive care unit , covid-19 , mechanical ventilation , disease , predictive value , severity of illness , retrospective cohort study , intensive care medicine , coronavirus , predictive value of tests , infectious disease (medical specialty)

This study evaluates the predictive value of circulating inflammatory markers, especially neopterin, in patients with coronavirus disease 2019 (COVID-19). Within this retrospective analysis of 115 hospitalized COVID-19 patients, elevated neopterin levels upon admission were significantly associated with disease severity, risk for intensive care unit admission, need for mechanical ventilation, and death. Therefore, neopterin is a reliable predictive marker in patients with COVID-19 and may help to improve the clinical management of patients.

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