Influence of Hepatitis C Coinfection and Treatment on Risk of Diabetes Mellitus in HIV-Positive Persons | Zendy

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Influence of Hepatitis C Coinfection and Treatment on Risk of Diabetes Mellitus in HIV-Positive Persons

Author(s) -

Amanda Mocroft,

Jens Lundgren,

Juergen Rockstroh,

Inka Aho,

Gilles Wandeler,

Lars N. Nielsen,

Simon Edwards,

JeanPaul Viard,

Karine Lacombe,

Gerd Fätkenheuer,

Giovanni Guaraldi,

Montserrat Laguno,

Josep Llibre,

Hila Elinav,

Leo Flamholc,

Martin Gisinger,

Dzmitry Paduta,

Irina Khromova,

David Jilich,

Błażej Rozpłochowski,

Cristiana Oprea,

Lars Peters,

Arjan Harxhi,

Marcelo Losso,

M Kundro,

Brigitte Schmied,

Robert Zangerle,

Igor Karpov,

A Vassilenko,

D. Paduto,

Nathan Clumeck,

Christoph Stephan,

M Delforge,

Éric Florence,

Linos Vandekerckhove,

Vesna Hadžiosmanović,

J Begovac,

Ladislav Machala,

D Sedlacek,

G Kronborg,

Thomas Benfield,

Jan Gerstoft,

Terese L. Katzenstein,

Christian Pedersen,

Işık Somuncu Johansen,

Lars Østergaard,

Lothar Wiese,

N F Møller,

Kai Zilmer,

J-P Viard,

PM Girard,

Christian Pradier,

E Fontas,

Claudine Duvivier,

Jürgen K. Rockstroh,

Georg M. N. Behrens,

Olaf Degen,

HansJürgen Stellbrink,

Johannes R. Bogner,

Nikoloz Chkhartishvili,

H Sambatakou,

Georgios Adamis,

N. Paissios,

János Szlávik,

Magnús Gottfreðsson,

Ciaran Kelly,

Luba Tau,

Dianna Turner,

Michael Burke,

Eduardo Shahar,

Gamal Hassoun,

M Haouzi,

Daniel Elbirt,

Antonella d’Arminio Monforte,

Roberto Esposito,

I. Mazeu,

C Mussini,

Francesco Mazzotta,

Andrea Gabbuti,

Adriano Lazzarin,

Antonella Castagna,

Nicola Gianotti,

Mara Gallí,

Anna Lisa Ridolfo,

Vilma Uždavinienė,

R Matulionyte,

T Staub,

R Hemmer,

S Dragas,

Mirjana Stevanović,

Peter Reiss,

Jasmina Trajanovska,

Dag Henrik Reikvam,

A Mæland,

Johan N. Bruun,

Brygida Knysz,

Jacek Gąsiorowski,

Małgorzata Inglot,

Elżbieta Bąkowska,

Robert Flisiak,

Anna Grzeszczuk,

Miłosz Parczewski,

Katarzyna Maciejewska,

Bogusz AksakWąs,

Marek Beniowski,

E. Mularska,

Elżbieta Jabłonowska,

Juliusz Kamerys,

Kamila Wójcik,

Iwona MozerLisewska,

Alexandra Zagalo,

Kamal Mansinho,

Fernando Maltêz,

Alexey Yakovlev,

Elena Kuzovatova,

Е. А. Бородулина,

Е. С. Вдоушкина,

Jovan Ranin,

J Tomazic,

José M Miró,

E Martinez,

Felipe García,

José Luís Blanco,

Marı́a Martı́nez-Rebollar,

Josep Mallolas,

Pilar Callau,

Juan Carlos Valerio-Rojas,

A Inciarta,

Santiago Moreno,

B Clotet,

Adriana Jou,

R Paredes,

J Puig,

Josep M. Llibre,

José Ramón Santos,

Pere Domingo,

Maria Gaby Rivero de Gutiérrez,

Gràcia Mateo,

M. A. Sambeat,

Jean-Marc Laporte,

Karolin Falconer,

Anders Thalme,

A Sonnerborg,

Carl Johan Treutiger,

AU Scherrer,

Raul Fernando Weber,

Matthias Cavassini,

Alexandra Calmy,

H Furrer,

Manuel Battegay,

P Schmid,

Anastasiia Kuznetsova,

Julia Mikhalik,

M Sluzhynska,

Ana Milinkovic,

A M Johnson,

Erica Simons,

Andrew Phillips,

M. A. Johnson,

Alan Winston,

Amy L. Clarke,

Clifford Leen,

Lasse Dam Rasmussen,

V Svedhem,

Justyna D. Kowalska,

Ole Kirk,

Anders Bojesen,

David Raben,

E V Hansen,

Daniel Tuyet Kristensen,

Jens Fromholt Larsen,

Andrew H. Fischer,

A Cozzi-Lepri,

Sarah Amele,

Annegret Pelchen–Matthews,

Ashley Roen

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa470

Subject(s) - medicine , coinfection , diabetes mellitus , hepatitis c , human immunodeficiency virus (hiv) , virology , endocrinology

Background The role of hepatitis C virus (HCV) coinfection and HCV-RNA in the development of diabetes mellitus (DM) in HIV-positive persons remains unclear. Methods Poisson regression was used to compare incidence rates of DM (blood glucose >11.1 mmol/L, HbA1C >6.5% or >48 mmol/mol, starting antidiabetic medicine or physician reported date of DM onset) between current HIV/HCV groups (anti-HCV-negative, spontaneously cleared HCV, chronic untreated HCV, successfully treated HCV, HCV-RNA-positive after HCV treatment). Results A total of 16 099 persons were included; at baseline 10 091 (62.7%) were HCV-Ab-negative, 722 (4.5%) were spontaneous clearers, 3614 (22.4%) were chronically infected, 912 (5.7%) had been successfully treated, and 760 (4.7%) were HCV-RNA-positive after treatment. During 136 084 person-years of follow-up (PYFU; median [interquartile range], 6.9 [3.6–13.2]), 1108 (6.9%) developed DM (crude incidence rate, 8.1/1000 PYFU; 95% CI, 7.7–8.6). After adjustment, there was no difference between the 5 HCV strata in incidence of DM (global P = .33). Hypertension (22.2%; 95% CI, 17.5%–26.2%) and body mass index >25 (22.0%; 95% CI, 10.4%–29.7%) had the largest population-attributable fractions for DM. Conclusions HCV coinfection and HCV cure were not associated with DM in this large study. The biggest modifiable risk factors were hypertension and obesity, and continued efforts to manage such comorbidities should be prioritized.

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