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Background Brain abscess and cerebritis are diseases associated with high-risk morbidity and mortality despite the advancement of imaging technologies and antimicrobial therapy for the past 30 years. We aimed to describe the demographics of patients with brain abscess and cerebritis at Mayo Clinic. Methods We retrospectively reviewed the demographics of all adult patients with the diagnosis of intracranial brain abscess, cerebritis, or both at our institution from January 1, 2009, through December 31, 2019. All analyses were performed using JMP software (Cary, NC). Results A total of 666 patients with brain abscess and cerebritis were identified during the study period. The median patient age was 59.7 years, and the majority were males (64.8%; P=0.0001). A total of 587 (88.1%) patients self-identified as Whites (P=&amp;lt; 0.0001) and 608 (91.2%) as Non-Hispanic or Latino (P=&amp;lt; 0.0001). A total of 453 (68.01%) patients were from the Midwest, with Minnesota and Wisconsin being the two most common States with 243 (36.4%; P=&amp;lt; 0.0001) and 101 (15.1%; P=0.01) patients respectively. The majority of patients (69.2%) had coronary artery disease and peripheral vascular disease with a median Charlson comorbidity index of 7 (P= &amp;lt; 0.0001) and an estimated 10-year survival of 0%. Conclusion Male, White Non-Hispanics, and elderly patients seem to be the most prevalent patient population at risk for brain abscess or cerebritis. This investigation provides clinicians the demographic data needed to identify potentially complex patients with brain abscesses. Disclosures M. Rizwan Sohail, MD, Aziyo Biologics (Consultant)Medtronic Inc (Consultant, Research Grant or Support)

344. Demographics of Patients with Brain Abscesses: A 10-year Mayo Clinic-Multicenter-Based Population Descriptive Study