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Background Acute pharyngitis is one of the most common causes of pediatric health care visits, accounting for approximately 12 million ambulatory care visits each year. Rapid antigen detection tests (RADTs) for Group A Streptococcus (GAS) are one of the most commonly ordered tests in the ambulatory settings. Approximately 40–60% of RADTs are estimated to be inappropriate. Determination of inappropriate RADT frequently requires time-intensive chart reviews. The purpose of this study was to determine if natural language processing (NLP) can provide an accurate and automated alternative for assessing RADT inappropriateness. Methods Patients ≥ 3 years of age who received an RADT while evaluated in our EDs/UCCs between April 2018 and September 2018 were identified. A manual chart review was completed on a 10% random sample to determine the presence of sore throat or viral symptoms (i.e., conjunctivitis, rhinorrhea, cough, diarrhea, hoarse voice, and viral exanthema). Inappropriate RADT was defined as either absence of sore throat or reporting 2 or more viral symptoms. An NLP algorithm was developed independently to assign the presence/absence of symptoms and RADT inappropriateness. The NLP sensitivity/specificity was calculated using the manual chart review sample as the gold standard. Results Manual chart review was completed on 720 patients, of which 320 (44.4%) were considered to have an inappropriate RADT. When compared to the manual review, the NLP approach showed high sensitivity (se) and specificity (sp) when assigning inappropriateness (88.4% and 90.0%, respectively). Optimal sensitivity/specificity was also observed for select symptoms, including sore throat (se: 92.9%, sp: 92.5%), cough (se: 94.5%, sp: 96.5%), and rhinorrhea (se: 86.1%, sp: 95.3%). The prevalence of clinical symptoms was similar when running NLP on subsequent, independent validation sets. After validating the NLP algorithm, a long term monthly trend report was developed. Figure Inappropriate GAS RADTs Determined by NLP, June 2018-May 2020 Conclusion An NLP algorithm can accurately identify inappropriate RADT when compared to a gold standard. Manual chart review requires dozens of hours to complete. In contrast, NLP requires only a couple of minutes and offers the potential to calculate valid metrics that are easily scaled-up to help monitor comprehensive, long-term trends. Disclosures Brian R. Lee, MPH, PhD, Merck (Grant/Research Support)

117. Natural Language Processing: An Automated Alternative to Determining Inappropriate Group A Streptococcal Testing