Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection | Zendy

Hongshuo Song | Zendy; Meera Bose | Zendy; Suteeraporn Pinyakorn | Zendy; Eric SandersBuell | Zendy; Anne Marie O’Sullivan | Zendy; Daniel Silas | Zendy; Rapee Trichavaroj | Zendy; Bessara Nuntapinit | Zendy; Phuc Pham | Zendy; Siriwat Akapirat | Zendy; Eugène Kroon | Zendy; Mark de Souza | Zendy; Robert Gramzinski | Zendy; Nelson L. Michael | Zendy; Merlin L. Robb | Zendy; Sandhya Vasan | Zendy; Sodsai Tovanabutra | Zendy; Jintanat Ananworanich | Zendy

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Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection

Author(s) -

Hongshuo Song,

Meera Bose,

Suteeraporn Pinyakorn,

Eric SandersBuell,

Anne Marie O’Sullivan,

Daniel Silas,

Rapee Trichavaroj,

Bessara Nuntapinit,

Phuc Pham,

Siriwat Akapirat,

Eugène Kroon,

Mark de Souza,

Robert Gramzinski,

Nelson L. Michael,

Merlin L. Robb,

Sandhya Vasan,

Sodsai Tovanabutra,

Jintanat Ananworanich

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa429

Subject(s) - virology , human immunodeficiency virus (hiv) , medicine , virus , genetic diversity , immunology , biology , population , environmental health

We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.

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