Limited Added Value of Oropharyngeal Swabs for Detecting Pneumococcal Carriage in Adults | Zendy

Jennifer L. Farrar | Zendy; Herine Odiembo | Zendy; Arthur Odoyo | Zendy; Godfrey Bigogo | Zendy; Lindsay Kim | Zendy; Fernanda C. Lessa | Zendy; Daniel R. Feikin | Zendy; Robert F. Breiman | Zendy; Cynthia G. Whitney | Zendy; M G Carvalho | Zendy; Fabiana Cristina Pimenta | Zendy

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Limited Added Value of Oropharyngeal Swabs for Detecting Pneumococcal Carriage in Adults

Author(s) -

Jennifer L. Farrar,

Herine Odiembo,

Arthur Odoyo,

Godfrey Bigogo,

Lindsay Kim,

Fernanda C. Lessa,

Daniel R. Feikin,

Robert F. Breiman,

Cynthia G. Whitney,

M G Carvalho,

Fabiana Cristina Pimenta

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa368

Subject(s) - carriage , medicine , isolation (microbiology) , streptococcus pneumoniae , pneumococcal infections , microbiology and biotechnology , antibiotics , biology , pathology

We compared pneumococcal isolation rates and evaluated the benefit of using oropharyngeal (OP) specimens in addition to nasopharyngeal (NP) specimens collected from adults in rural Kenya. Of 846 adults, 52.1% were colonized; pneumococci were detected from both NP and OP specimens in 23.5%, NP only in 22.9%, and OP only in 5.7%. Ten-valent pneumococcal conjugate vaccine strains were detected from both NP and OP in 3.4%, NP only in 4.1%, and OP only in 0.7%. Inclusion of OP swabs increased carriage detection by 5.7%; however, the added cost of collecting and processing OP specimens may justify exclusion from future carriage studies among adults.

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