Increasing Drug Resistance Among Persons With Tuberculosis in Massachusetts, 2009–2018 | Zendy

Jared J Eddy | Zendy; Kavita M Gadani | Zendy; Andrew Tibbs | Zendy; John Bernardo | Zendy; Jennifer Cochran | Zendy; Laura F. White | Zendy; C. Robert Horsburgh | Zendy; Karen R. Jacobson | Zendy

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Increasing Drug Resistance Among Persons With Tuberculosis in Massachusetts, 2009–2018

Author(s) -

Jared J Eddy,

Kavita M Gadani,

Andrew Tibbs,

John Bernardo,

Jennifer Cochran,

Laura F. White,

C. Robert Horsburgh,

Karen R. Jacobson

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa300

Subject(s) - medicine , isoniazid , tuberculosis , confidence interval , odds ratio , drug resistance , extensively drug resistant tuberculosis , mycobacterium tuberculosis , microbiology and biotechnology , pathology , biology

We examined Massachusetts tuberculosis surveillance data from to 2009 to 2018. Of 1533 culture-confirmed cases, 190 (12.4%) demonstrated resistance to isoniazid including 32 (2.1%) with rifampin resistance. In multivariable analysis, isoniazid resistance increased significantly over time (per-year odds ratio = 1.07, 95% confidence interval = 1.01–1.13, P = .018) and was associated with younger age, foreign birth, and prior tuberculosis treatment.

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