Genetic Heterogeneity of Australian Candida auris Isolates: Insights From a Nonoutbreak Setting Using Whole-Genome Sequencing | Zendy

Chayanika Biswas | Zendy; Qinning Wang | Zendy; Sebastiaan J. van Hal | Zendy; David W. Eyre | Zendy; Bernard Hudson | Zendy; Catriona Halliday | Zendy; Krystyna Mazsewska | Zendy; Alice Kizny Gordon | Zendy; Andie Lee | Zendy; László Irinyi | Zendy; Christopher H. Heath | Zendy; Arunaloke Chakrabarti | Zendy; Nelesh P. Govender | Zendy; Wieland Meyer | Zendy; Vitali Sintchenko | Zendy; Sharon C.A. Chen | Zendy

Open Access

Genetic Heterogeneity of Australian Candida auris Isolates: Insights From a Nonoutbreak Setting Using Whole-Genome Sequencing

Author(s) -

Chayanika Biswas,

Qinning Wang,

Sebastiaan J. van Hal,

David W. Eyre,

Bernard Hudson,

Catriona Halliday,

Krystyna Mazsewska,

Alice Kizny Gordon,

Andie Lee,

László Irinyi,

Christopher H. Heath,

Arunaloke Chakrabarti,

Nelesh P. Govender,

Wieland Meyer,

Vitali Sintchenko,

Sharon C.A. Chen

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa158

Subject(s) - candida auris , whole genome sequencing , medicine , genome , dna sequencing , genetic heterogeneity , computational biology , genetics , evolutionary biology , biology , dna , antifungal , gene , phenotype , dermatology

Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigating C. auris infections.

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