Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology | Zendy

Yijin Wang | Zendy; Hongyang Liu | Zendy; Yiyun Jiang | Zendy; Qiuwei Pan | Zendy; Jingmin Zhao | Zendy

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Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology

Author(s) -

Yijin Wang,

Hongyang Liu,

Yiyun Jiang,

Qiuwei Pan,

Jingmin Zhao

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa107

Subject(s) - medicine , etiology , superinfection , exacerbation , hepatitis e virus , gastroenterology , hepatitis e , cirrhosis , hepatitis , immunology , virus , biochemistry , chemistry , genotype , gene

Background: Chronic liver diseases (CLDs) have been documented to exacerbate clinical outcomes of acute hepatitis E (AHE). This study aimed to uncover the role of etiology and status of CLD in the adverse outcomes of AHE. We found that superinfection with hepatitis E virus (HEV) in patients with cirrhotic CLD can cause a worsen outcome, leading to exacerbation of AHE, compared with HEV-infected patients without CLD or with noncirrhotic CLD. Additional analysis revealed that the etiology of CLD is not associated with outcomes of AHE patients. These finding suggests that the overall liver status plays a predominant role in determining the outcomes of AHE.

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