Microbiome Restoration by RBX2660 Does Not Preclude Recurrence of Multidrug-Resistant Urinary Tract Infection Following Subsequent Antibiotic Exposure: A Case Report | Zendy

Eric C. Keen | Zendy; P. Tasoff | Zendy; Tiffany Hink | Zendy; Kimberly A. Reske | Zendy; CareyAnn D. Burnham | Zendy; Gautam Dantas | Zendy; Jennie H. Kwon | Zendy; Erik R. Dubberke | Zendy

Open Access

Microbiome Restoration by RBX2660 Does Not Preclude Recurrence of Multidrug-Resistant Urinary Tract Infection Following Subsequent Antibiotic Exposure: A Case Report

Author(s) -

Eric C. Keen,

P. Tasoff,

Tiffany Hink,

Kimberly A. Reske,

CareyAnn D. Burnham,

Gautam Dantas,

Jennie H. Kwon,

Erik R. Dubberke

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa042

Subject(s) - microbiome , medicine , urinary system , antibiotics , carriage , multiple drug resistance , microbiology and biotechnology , bioinformatics , biology , pathology

A 62-year-old woman received RBX2660, an investigational microbiome restoration therapeutic, for recurrent multidrug-resistant (MDR) urinary tract infection (UTI). RBX2660 increased gut microbiome diversity but did not eliminate uropathogen carriage, and MDR UTI recurred after subsequent antibiotic exposure. Thus, restoration of microbiome diversity does not preclude disease recurrence by residual MDR pathogens.

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