Soluble T-Cell Immunoglobulin Mucin Domain-3 Is Associated With Hepatitis C Virus Coinfection and Low-Grade Inflammation During Chronic Human Immunodeficiency Virus Infection | Zendy

Hedda Hoel | Zendy; Thor Ueland | Zendy; Malene HoveSkovsgaard | Zendy; Hans Jakob Hartling | Zendy; Marco Gelpi | Zendy; Thomas Benfield | Zendy; Henrik Ullum | Zendy; Annika E. Michelsen | Zendy; Pål Aukrust | Zendy; Susanne Dam Nielsen | Zendy; Marius Trøseid | Zendy

Open Access

Soluble T-Cell Immunoglobulin Mucin Domain-3 Is Associated With Hepatitis C Virus Coinfection and Low-Grade Inflammation During Chronic Human Immunodeficiency Virus Infection

Author(s) -

Hedda Hoel,

Thor Ueland,

Malene HoveSkovsgaard,

Hans Jakob Hartling,

Marco Gelpi,

Thomas Benfield,

Henrik Ullum,

Annika E. Michelsen,

Pål Aukrust,

Susanne Dam Nielsen,

Marius Trøseid

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa033

Subject(s) - coinfection , medicine , immunology , cohort , hepatitis c virus , immune system , inflammation , viremia , antibody , virus , virology

Levels of sTim-3 decreased after ART initiation. In a cross-sectional cohort, levels of sTIM-3 were higher in PWH than in controls and were independently associated with HCV coinfection and high-sensitivity C-reactive protein, representing a potential link between immune exhaustion, inflammation, and risk of comorbidities.

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