Escherichia coli O8:H8 Carrying a Novel Variant of the Heat-Labile Enterotoxin LT2 Gene Caused Outbreaks of Diarrhea | Zendy

Kai Ishimaru | Zendy; Mari Sasaki | Zendy; Hiroshi Narimatsu | Zendy; Yoko Arimizu | Zendy; Yasuhiro Gotoh | Zendy; Keiji Nakamura | Zendy; Tetsuya Hayashi | Zendy; Yoshitoshi Ogura | Zendy

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Escherichia coli O8:H8 Carrying a Novel Variant of the Heat-Labile Enterotoxin LT2 Gene Caused Outbreaks of Diarrhea

Author(s) -

Kai Ishimaru,

Mari Sasaki,

Hiroshi Narimatsu,

Yoko Arimizu,

Yasuhiro Gotoh,

Keiji Nakamura,

Tetsuya Hayashi,

Yoshitoshi Ogura

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa021

Subject(s) - escherichia coli , enterotoxin , microbiology and biotechnology , outbreak , heat labile enterotoxin , diarrhea , virulence , prophage , gene , pathogen , biology , virology , medicine , genetics , bacteriophage

No outbreaks caused by -producing heat-labile enterotoxin LT2 have been reported to date. Here, we revealed that the O8:H8 strains isolated from patients in 2 independent diarrhea outbreaks were negative for any known virulence determinants in routine microbiological tests, were very closely related, and carried a prophage-encoded gene for a novel LT2 variant (LT2d) and the genes for colonization factor antigen III. We also showed that LT2d has a cytotonic activity similar to LT1. These data indicate the importance of strains producing LT2d as a human pathogen.

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