Repeated Syphilis Episodes in HIV-Infected Men Who Have Sex With Men: A Multicenter Prospective Cohort Study on Risk Factors and the Potential Role of Syphilis Immunity
Author(s) -
Benno Röthlisberger,
Fabian Franzeck,
Suraj Balakrishna,
Stephan Lautenschlager,
Maria Christine Thurnheer,
Laurence Toutous Trellu,
Matthias Cavassini,
Pietro Vernazza,
Enos Bernasconi,
Dominique L. Braun,
Roger D. Kouyos,
Manuel Battegay,
A Anagnostopoulos,
Jürg Böni,
Heiner C. Bucher,
Alexandra Calmy,
Angela Ciuffi,
G Dollenmaier,
Matthias Egger,
Luigia Elzi,
Jan Fehr,
Jacques Fellay,
Hansjakob Furrer,
Christoph A. Fux,
Huldrych F. Günthard,
D Haerry,
Barbara Hasse,
Hans H. Hirsch,
Matthew Hoffmann,
Irène Hösli,
Markus Huber,
Christian R. Kahlert,
Laurent Kaiser,
Olivia Keiser,
Thomas Klimkait,
Helen Kovari,
Bruno Ledergerber,
G Martinetti,
Begoña Martínez de Tejada,
Catia Marzolini,
Karin J. Metzner,
Nicolas Müller,
Dunja Nicca,
P Paioni,
Giuseppe Pantaleo,
M Perreau,
Andri Rauch,
Charles M. Rudin,
Alexandra Scherrer,
Patrick Schmid,
René Speck,
Michael Stöckle,
Philip Tarr,
Alexandra Trkola,
Gilles Wandeler,
Rachel Weber,
Sabine Yerly
Publication year - 2020
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofaa019
Subject(s) - syphilis , medicine , men who have sex with men , prospective cohort study , hazard ratio , cohort study , immunology , cohort , risk factor , epidemiology , confidence interval , demography , human immunodeficiency virus (hiv) , sociology
In HIV-infected MSM, we observed no indication of decreased syphilis risk with repeated syphilis episodes. The extent of sexual risk behavior over time was the strongest risk factor for repeated syphilis episodes. The observed association of antiretroviral therapy with repeated syphilis episodes warrants further immunological and epidemiological investigation.
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