Cardiovascular Biomarker Profile on Antiretroviral Therapy Is Not Influenced by History of an IRIS Event in People With HIV and Suppressed Viremia | Zendy

Aurélie GouelChéron | Zendy; Martha Nason | Zendy; Adam Rupert | Zendy; Virginia Sheikh | Zendy; Greg Robby | Zendy; Gary A. Fahle | Zendy; Irini Sereti | Zendy

Open Access

Cardiovascular Biomarker Profile on Antiretroviral Therapy Is Not Influenced by History of an IRIS Event in People With HIV and Suppressed Viremia

Author(s) -

Aurélie GouelChéron,

Martha Nason,

Adam Rupert,

Virginia Sheikh,

Greg Robby,

Gary A. Fahle,

Irini Sereti

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa017

Subject(s) - medicine , viremia , immune reconstitution inflammatory syndrome , inflammation , antiretroviral therapy , immunology , biomarker , proinflammatory cytokine , iris (biosensor) , viral load , human immunodeficiency virus (hiv) , biochemistry , chemistry , computer security , computer science , biometrics

Immune reconstitution inflammatory syndrome (IRIS) is characterized by release of proinflammatory cytokines and tissue inflammation occurring early after antiretroviral therapy (ART) initiation. The role of previous IRIS events in persistent chronic inflammation in people with HIV is currently unclear. In this retrospective analysis of 143 participants who maintained suppression of HIV viremia, we compared biomarkers related to inflammation, coagulation, and cardiovascular risk after 3 years on ART in participants with and without a history of IRIS. There was no evidence of higher levels of persistent chronic inflammation in people with HIV who had a history of an IRIS event. . NCT00286767.

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