Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice | Zendy

Jeffrey E. Gotts | Zendy; Jason Abbott | Zendy; Xiaohui Fang | Zendy; Haru Yanagisawa | Zendy; Naoki Takasaka | Zendy; Stephen L. Nishimura | Zendy; Carolyn S. Calfee | Zendy; Michael A. Matthay | Zendy

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Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice

Author(s) -

Jeffrey E. Gotts,

Jason Abbott,

Xiaohui Fang,

Haru Yanagisawa,

Naoki Takasaka,

Stephen L. Nishimura,

Carolyn S. Calfee,

Michael A. Matthay

Publication year - 2017

Publication title -

nicotine and tobacco research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.338

H-Index - 113

eISSN - 1469-994X

pISSN - 1462-2203

DOI - 10.1093/ntr/ntx062

Subject(s) - bronchoalveolar lavage , medicine , neutrophilia , lung , pulmonary edema , ards , edema , lipopolysaccharide , immunology , pathology , diffuse alveolar damage , cytokine , pharmacology , acute respiratory distress

Cigarette smoking (CS) remains a major public health concern and has recently been associated with an increased risk of developing acute respiratory distress syndrome (ARDS). Bronchoalveolar lavage (BAL) experiments in human volunteers have demonstrated that active smokers develop increased alveolar-epithelial barrier permeability to protein after inhaling lipopolysaccharide (LPS). Here we tested the hypothesis that short-term whole-body CS exposure would increase LPS-induced lung edema in mice.

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