HIV-1 Proteins Influence Novelty-Seeking Behavior and Alter Region-Specific Transcriptional Responses to Chronic Nicotine Treatment in HIV-1Tg Rats | Zendy

Zhongli Yang | Zendy; Tanseli Nesil | Zendy; Taylor Wingo | Zendy; Sulie L. Chang | Zendy; Ming D. Li | Zendy

Open Access

HIV-1 Proteins Influence Novelty-Seeking Behavior and Alter Region-Specific Transcriptional Responses to Chronic Nicotine Treatment in HIV-1Tg Rats

Author(s) -

Zhongli Yang,

Tanseli Nesil,

Taylor Wingo,

Sulie L. Chang,

Ming D. Li

Publication year - 2017

Publication title -

nicotine and tobacco research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.338

H-Index - 113

eISSN - 1469-994X

pISSN - 1462-2203

DOI - 10.1093/ntr/ntx047

Subject(s) - nucleus accumbens , ventral tegmental area , nicotine , prefrontal cortex , novelty seeking , addiction , dopamine , population , pharmacology , brain stimulation reward , open field , medicine , biology , psychology , neuroscience , cognition , social psychology , environmental health , dopaminergic , personality , temperament

Clinical studies suggest that HIV-1-infected patients are more likely to use or abuse addictive drugs than is the general population. We hypothesized that HIV-1 proteins impact novelty-seeking behavior and enhance the transcriptional response to nicotine in genes implicated in both novelty-seeking behavior and drug addiction.

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