Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans | Zendy

Whitney E. Melroy-Greif | Zendy; Matthew A. Simonson | Zendy; Robin P. Corley | Zendy; Sharon M. Lutz | Zendy; John E. Hokanson | Zendy; Marissa A. Ehringer | Zendy

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Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans

Author(s) -

Whitney E. Melroy-Greif,

Matthew A. Simonson,

Robin P. Corley,

Sharon M. Lutz,

John E. Hokanson,

Marissa A. Ehringer

Publication year - 2016

Publication title -

nicotine and tobacco research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.338

H-Index - 113

eISSN - 1469-994X

pISSN - 1462-2203

DOI - 10.1093/ntr/ntw200

Subject(s) - nicotine , nicotinic agonist , downregulation and upregulation , cholinergic , acetylcholine receptor , gene , smoking cessation , set (abstract data type) , nicotine dependence , biology , medicine , genetics , receptor , neuroscience , computer science , pathology , programming language

Cigarette smoking is a physiologically harmful habit. Nicotinic acetylcholine receptors (nAChRs) are bound by nicotine and upregulated in response to chronic exposure to nicotine. It is known that upregulation of these receptors is not due to a change in mRNA of these genes, however, more precise details on the process are still uncertain, with several plausible hypotheses describing how nAChRs are upregulated. We have manually curated a set of genes believed to play a role in nicotine-induced nAChR upregulation. Here, we test the hypothesis that these genes are associated with and contribute risk for nicotine dependence (ND) and the number of cigarettes smoked per day (CPD).

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