Open AccessCYP2A6Effects on Subjective Reactions to Initial Smoking Attempt
Author(s) -
Dale S. Can,
Robin J. Mermelstein,
Tait R. Medina,
Oksana Pugach,
Donald Hedeker,
Robert B. Weiss
Publication year - 2015
Publication title -
nicotine and tobacco research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 113
eISSN - 1469-994X
pISSN - 1462-2203
DOI - 10.1093/ntr/ntv244
Subject(s) - cyp2a6 , nicotine , medicine , metabolism , cytochrome p450 , cyp1a2
In very novice smokers, CYP2A6 genotypes that reduce nicotine metabolism to an intermediate rate may increase smoking risk, relative to both normal and slow rates. The present study examined the hypothesis that intermediate metabolism variants are associated with greater pleasurable effects of the initial smoking attempt than either normal or slow metabolism variants.
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