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The Reinforcing Effects of Nicotine in Humans and Nonhuman Primates: A Review of Intravenous Self-Administration Evidence and Future Directions for Research
Author(s) -
Amy Goodwin,
Takato Hiranita,
Merle G. Paule
Publication year - 2015
Publication title -
nicotine and tobacco research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 113
eISSN - 1469-994X
pISSN - 1462-2203
DOI - 10.1093/ntr/ntv002
Subject(s) - nicotine , self administration , abuse liability , psychology , addiction , smoking cessation , alkaloid , pharmacology , reinforcement , medicine , drug , psychiatry , social psychology , chemistry , pathology , stereochemistry
Cigarette smoking is largely driven by the reinforcing properties of nicotine. Intravenous (IV) self-administration procedures are the gold standard for investigating the reinforcing effects of psychoactive drugs. The goal of this review was to examine the results of published investigations of the reinforcing effects of nicotine measured using IV self-administration procedures in humans and nonhuman primates.

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