Abuse Potential of Non-Nicotine Tobacco Smoke Components: Acetaldehyde, Nornicotine, Cotinine, and Anabasine | Zendy

A. C. Hoffman | Zendy; Scott E. Evans | Zendy

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Abuse Potential of Non-Nicotine Tobacco Smoke Components: Acetaldehyde, Nornicotine, Cotinine, and Anabasine

Author(s) -

A. C. Hoffman,

Scott E. Evans

Publication year - 2012

Publication title -

nicotine and tobacco research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.338

H-Index - 113

eISSN - 1469-994X

pISSN - 1462-2203

DOI - 10.1093/ntr/nts192

Subject(s) - nornicotine , anabasine , nicotine , cotinine , acetaldehyde , alkaloid , pharmacology , medicine , tobacco smoke , psychology , psychiatry , chemistry , environmental health , ethanol , biochemistry , stereochemistry

This review identified published animal studies evaluating the possible abuse potential of acetaldehyde, nornicotine, cotinine, and anabasine based on five commonly used paradigms. These include their effects on midbrain dopamine (DA) levels, drug discrimination and substitution for known drugs of abuse, place conditioning, self-administration behavior, and somatic withdrawal symptoms.

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