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Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study
Author(s) -
Henry R. Kranzler,
Yukiko Washio,
Leah R. Zindel,
Kevin G. Lynch,
Dennis J. Hand,
Rachel F. Tyndale,
Cheryl Oncken,
Robert A. Schnoll
Publication year - 2020
Publication title -
nicotine and tobacco research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 113
eISSN - 1469-994X
pISSN - 1462-2203
DOI - 10.1093/ntr/ntaa066
Subject(s) - cotinine , medicine , methadone , metabolite , opioid , nicotine , buprenorphine , placebo , anesthesia , receptor , alternative medicine , pathology
Pregnant women exposed chronically to opioids smoked more cigarettes per day (CPD) and had a higher nicotine metabolite ratio (NMR), 3-hydroxycotinine/cotinine, a biomarker of nicotine metabolism and clearance, than those not receiving opioids. We examined CPD and NMR in a group of pregnant smokers, a quarter of whom were receiving opioid agonist therapy (OAT).

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