Metabolic reprogramming in cancer: the bridge that connects intracellular stresses and cancer behaviors | Zendy

Yi Zhou | Zendy; Huiyan Sun | Zendy; Ying Xu | Zendy

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Metabolic reprogramming in cancer: the bridge that connects intracellular stresses and cancer behaviors

Author(s) -

Yi Zhou,

Huiyan Sun,

Ying Xu

Publication year - 2020

Publication title -

national science review

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.433

H-Index - 54

eISSN - 2095-5138

pISSN - 2053-714X

DOI - 10.1093/nsr/nwaa082

Subject(s) - intracellular , reprogramming , cancer , cancer cell , bridge (graph theory) , metastasis , biology , microbiology and biotechnology , cell , cancer research , biochemistry , genetics , anatomy

Extensive changes in cellular metabolisms have been observed in cancer. They are probably induced by the same intracellular stressor, persistent off-balance in intracellular pH across possibly all adult cancers. It is these altered metabolisms that gives rise to a variety of cancerous behaviors such as continuous cell division, metastasis and drug resistance.

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