Open AccessGenotype-based gene signature of glioma risk
Author(s) -
YenTsung Huang,
Yi Zhang,
Zhijin Wu,
Dominique S. Michaud
Publication year - 2016
Publication title -
neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/now288
Subject(s) - glioma , genome wide association study , expression quantitative trait loci , genotype , biology , gene signature , gene , genetic association , logistic regression , computational biology , gene expression , genetics , oncology , single nucleotide polymorphism , medicine
Glioma accounts for 80% of malignant brain tumors, but its etiologic determinants remain elusive. Despite genetic susceptibility loci identified by genome-wide association study (GWAS), the agnostic approach leaves open the possibility that other susceptibility genes remain to be discovered. Here we conduct a gene-centric integrative GWAS (iGWAS) of glioma risk that combines transcriptomics and genetics.
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