Open AccessSMOmutation status defines a distinct and frequent molecular subgroup in olfactory groove meningiomas
Author(s) -
Julien Boetto,
Franck Bielle,
Marc Sanson,
Matthieu Peyre,
Michel Kalamarides
Publication year - 2016
Publication title -
neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/now276
Subject(s) - sanger sequencing , mutant , akt1 , mutation , meningioma , medicine , cancer research , oncology , biology , gastroenterology , pathology , gene , genetics , protein kinase b , signal transduction
Meningiomas are the most common primary intracranial tumors in adults. Identification of SMO and AKT1 mutations in meningiomas has raised the hope for targeted therapies. It would be useful to know the precise frequency of these mutations in anatomical subgroups and clarify their prognostic value.
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