Open AccessSignificance of low mTORC1 activity in defining the characteristics of brain tumor stem cells
Author(s) -
Yipeng Han,
Atsushi Enomoto,
Yukihiro Shiraki,
Shen-Qi Wang,
Xiaoze Wang,
Shinya Toyokuni,
Naoya Asai,
Kaori Ushida,
Hosne Ara,
Fumiharu Ohka,
Toshihiko Wakabayashi,
Jie Ma,
Atsushi Natsume,
Masahide Takahashi
Publication year - 2016
Publication title -
neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/now237
Subject(s) - mtorc1 , stem cell , biology , cancer research , cancer stem cell , neural stem cell , microbiology and biotechnology , pi3k/akt/mtor pathway , signal transduction
The significance of mammalian target of rapamycin complex 1 (mTORC1) activity in the maintenance of cancer stem cells (CSCs) remains controversial. Previous findings showed that mTORC1 activation depleted the population of leukemia stem cells in leukemia, while maintaining the stemness in pancreatic CSCs. The purpose of this study was to examine the currently unknown role and significance of mTORC1 activity in brain tumor stem cells (BTSCs).
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