Open AccessInhibition of glioblastoma tumorspheres by combined treatment with 2-deoxyglucose and metformin
Author(s) -
Eui Hyun Kim,
Ji-Hyun Lee,
Yoonjee Oh,
Ilkyoo Koh,
JinKyoung Shim,
Junseong Park,
Junjeong Choi,
Mijin Yun,
Jeong Yong Jeon,
YongMin Huh,
Jong Hee Chang,
Sun Ho Kim,
KyungSup Kim,
JaeHo Cheong,
Pilnam Kim,
SeokGu Kang
Publication year - 2016
Publication title -
neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/now174
Subject(s) - deoxyglucose , metformin , glioblastoma , medicine , oncology , cancer research , insulin
Deprivation of tumor bioenergetics by inhibition of multiple energy pathways has been suggested as an effective therapeutic approach for various human tumors. However, this idea has not been evaluated in glioblastoma (GBM). We hypothesized that dual inhibition of glycolysis and oxidative phosphorylation could effectively suppress GBM tumorspheres (TS).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom