Open AccessLimited role for transforming growth factor–β pathway activation-mediated escape from VEGF inhibition in murine glioma models
Author(s) -
Davide Mangani,
Michael Weller,
Emad Seyed Sadr,
Edith Willscher,
Katharina Seystahl,
Guido Reifenberger,
Ghazaleh Tabatabai,
Hans Binder,
Hannah Schneider
Publication year - 2016
Publication title -
neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/now112
Subject(s) - angiogenesis , cancer research , glioma , vascular endothelial growth factor , transforming growth factor , biology , in vivo , transforming growth factor beta , vascular endothelial growth factor a , signal transduction , immune system , immunology , microbiology and biotechnology , vegf receptors
The vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-β pathways regulate key biological features of glioblastoma. Here we explore whether the TGF-β pathway, which promotes angiogenesis, invasiveness, and immunosuppression, acts as an escape pathway from VEGF inhibition.
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