Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas | Zendy

Janet L. Oblinger | Zendy; Sarah S. Burns | Zendy; Elena M. Akhmametyeva | Zendy; Jie Huang | Zendy; Pan Li | Zendy; Yulin Ren | Zendy; Rulong Shen | Zendy; Beth A. MilesMarkley | Zendy; Aaron C. Moberly | Zendy; A. Douglas Kinghorn | Zendy; D. Bradley Welling | Zendy; LongSheng Chang | Zendy

Open Access

Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas

Author(s) -

Janet L. Oblinger,

Sarah S. Burns,

Elena M. Akhmametyeva,

Jie Huang,

Pan Li,

Yulin Ren,

Rulong Shen,

Beth A. MilesMarkley,

Aaron C. Moberly,

A. Douglas Kinghorn,

D. Bradley Welling,

LongSheng Chang

Publication year - 2016

Publication title -

neuro-oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.005

H-Index - 125

eISSN - 1523-5866

pISSN - 1522-8517

DOI - 10.1093/neuonc/now032

Subject(s) - cancer research , biology , eif4e , xiap , tumor progression , microbiology and biotechnology , apoptosis , cancer , programmed cell death , caspase , translation (biology) , biochemistry , genetics , messenger rna , gene

The eukaryotic initiation factor 4F (eIF4F) complex plays a pivotal role in protein translation initiation; however, its importance in malignant and benign Schwann cell tumors has not been explored, and whether blocking eIF4F function is effective for treating these tumors is not known.

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