Supratentorial clear cell ependymomas with branching capillaries demonstrate characteristic clinicopathological features and pathological activation of nuclear factor-kappaB signaling | Zendy

Dominique Figarella-Branger | Zendy; Emmanuèle Lechapt | Zendy; Émeline Tabouret | Zendy; Stephanie T. Jünger | Zendy; A. Maues de Paula | Zendy; Corinne Bouvier | Zendy; Carole Colin | Zendy; Anne Jouvet | Zendy; Fabien Forest | Zendy; Felipe Andreiuolo | Zendy; Isabelle QuintinRoué | Zendy; MarieChristine Machet | Zendy; Anne Heitzmann | Zendy; Serge Milin | Zendy; Henri Sevestre | Zendy; Catherine Godfraind | Zendy; François Labrousse | Zendy; Philippe Métellus | Zendy; Didier Scavarda | Zendy; Torsten Pietsch | Zendy

Open Access

Supratentorial clear cell ependymomas with branching capillaries demonstrate characteristic clinicopathological features and pathological activation of nuclear factor-kappaB signaling

Author(s) -

Dominique Figarella-Branger,

Emmanuèle Lechapt,

Émeline Tabouret,

Stephanie T. Jünger,

A. Maues de Paula,

Corinne Bouvier,

Carole Colin,

Anne Jouvet,

Fabien Forest,

Felipe Andreiuolo,

Isabelle QuintinRoué,

MarieChristine Machet,

Anne Heitzmann,

Serge Milin,

Henri Sevestre,

Catherine Godfraind,

François Labrousse,

Philippe Métellus,

Didier Scavarda,

Torsten Pietsch

Publication year - 2016

Publication title -

neuro-oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.005

H-Index - 125

eISSN - 1523-5866

pISSN - 1522-8517

DOI - 10.1093/neuonc/now025

Subject(s) - biology , ependymoma , pathology , histogenesis , pathological , immunohistochemistry , cancer research , medicine , immunology

Clear cell ependymoma is one of the 4 main histological subtypes of ependymomas defined by the World Health Organization (WHO) classification of tumors of the CNS. DNA methylation profiling can distinguish 4 subgroups of intracranial ependymomas, including supratentorial (ST) ependymomas with Yes-associated protein 1 fusion (YAP1), ST ependymomas with fusion of v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), posterior fossa ependymomas with balanced genome, and posterior fossa ependymomas with chromosomal instability. In addition, trisomy 19 is a genomic hallmark of ependymomas with rich branching capillaries. However, the relation of histological and molecular subtypes is unclear.

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