Glycolysis and the pentose phosphate pathway are differentially associated with the dichotomous regulation of glioblastoma cell migration versus proliferation | Zendy

Annegret Kathagen-Buhmann | Zendy; Alexander Schulte | Zendy; Jonathan Weller | Zendy; Mareike Holz | Zendy; Christel HeroldMende | Zendy; Rainer Glaß | Zendy; Katrin Lamszus | Zendy

Open Access

Glycolysis and the pentose phosphate pathway are differentially associated with the dichotomous regulation of glioblastoma cell migration versus proliferation

Author(s) -

Annegret Kathagen-Buhmann,

Alexander Schulte,

Jonathan Weller,

Mareike Holz,

Christel HeroldMende,

Rainer Glaß,

Katrin Lamszus

Publication year - 2016

Publication title -

neuro-oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.005

H-Index - 125

eISSN - 1523-5866

pISSN - 1522-8517

DOI - 10.1093/neuonc/now024

Subject(s) - pentose phosphate pathway , gene knockdown , downregulation and upregulation , glycolysis , cell growth , biology , anaerobic glycolysis , metabolic pathway , microbiology and biotechnology , enzyme , cancer research , biochemistry , apoptosis , gene

The dichotomy between glioblastoma cell migration and proliferation is regulated by various parameters including oxygen tension. In glioblastoma stem-like cells, hypoxia induces downregulation of pentose phosphate pathway (PPP) enzymes and a flux shift towards glycolysis. We investigated whether the 2 parallel glucose metabolic pathways are intrinsically linked with cell function and whether these pathways are mechanistically involved in regulating functional programs.

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