Classification based on mutations ofTERTpromoter andIDHcharacterizes subtypes in grade II/III gliomas
Author(s) -
Pei Yang,
Jinquan Cai,
Wei Yan,
Wei Zhang,
Yinyan Wang,
Baoshi Chen,
Guilin Li,
Shouwei Li,
Chenxing Wu,
Kun Yao,
Wenbin Li,
Xiaoxia Peng,
Yongping You,
Ling Chen,
Chuanlu Jiang,
Xiaoguang Qiu,
Tao Jiang
Publication year - 2016
Publication title -
neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/now021
Subject(s) - microbiology and biotechnology , glioma , mutation , biology , cancer research , gene , genetics
Grade II and III gliomas have variable clinical behaviors, showing the distinct molecular genetic alterations from glioblastoma (GBM), many of which eventually transform into more aggressive tumors. Since the classifications of grade II/III gliomas based on the genetic alterations have been recently emerging, it is now a trend to include molecular data into the standard diagnostic algorithm of glioma.
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