Open AccessSurvivin transcript variant 2 drives angiogenesis and malignant progression in proneural gliomas
Author(s) -
Tiffany Doucette,
K. Latha,
Yuhui Yang,
Gregory N. Fuller,
Arvind Rao,
Ganesh Rao
Publication year - 2014
Publication title -
neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/nou034
Subject(s) - survivin , glioma , angiogenesis , biology , cancer research , ectopic expression , tumor progression , in vivo , apoptosis , pathology , medicine , gene , genetics
The influence of survivin isoforms on outcome in glioblastoma is poorly understood. We analyzed the dominant anti-apoptotic transcript variants of survivin using expression data and modeled them in vivo to determine their impact on glioma formation and progression.
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