The deadly connection between endoplasmic reticulum, Ca2+, protein synthesis, and the endoplasmic reticulum stress response in malignant glioma cells | Zendy

Guyla G. Johnson | Zendy; Misti C. White | Zendy; Jian-He Wu | Zendy; Matthew Vallejo | Zendy; M. Grimaldi | Zendy

Open Access

The deadly connection between endoplasmic reticulum, Ca2+, protein synthesis, and the endoplasmic reticulum stress response in malignant glioma cells

Author(s) -

Guyla G. Johnson,

Misti C. White,

Jian-He Wu,

Matthew Vallejo,

M. Grimaldi

Publication year - 2014

Publication title -

neuro-oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.005

H-Index - 125

eISSN - 1523-5866

pISSN - 1522-8517

DOI - 10.1093/neuonc/nou012

Subject(s) - unfolded protein response , endoplasmic reticulum , glioma , microbiology and biotechnology , translocon , programmed cell death , biology , stim1 , cancer research , chemistry , apoptosis , biochemistry , membrane protein , membrane

The endoplasmic reticulum (ER) is involved in Ca(2+) signaling and protein processing. Accumulation of unfolded proteins following ER Ca(2+) depletion triggers the ER stress response (ERSR), which facilitates protein folding and removal of damaged proteins and can induce cell death. Unfolded proteins bind to chaperones, such as the glucose-regulated protein (GRP)78 and cause the release of GRP78-repressed proteins executing ERSR.

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