Historical benchmarks for medical therapy trials in surgery- and radiation-refractory meningioma: a RANO review | Zendy

Thomas Kaley | Zendy; Igor J. Barani | Zendy; M. C. Chamberlain | Zendy; Michael McDermott | Zendy; K. Panageas | Zendy; Jeffrey J. Raizer | Zendy; Lisa R. Rogers | Zendy; D. Schiff | Zendy; Michael A. Vogelbaum | Zendy; Dorothea Weber | Zendy; Patrick Y. Wen | Zendy

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Historical benchmarks for medical therapy trials in surgery- and radiation-refractory meningioma: a RANO review

Author(s) -

Thomas Kaley,

Igor J. Barani,

M. C. Chamberlain,

Michael McDermott,

K. Panageas,

Jeffrey J. Raizer,

Lisa R. Rogers,

D. Schiff,

Michael A. Vogelbaum,

Dorothea Weber,

Patrick Y. Wen

Publication year - 2014

Publication title -

neuro-oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.005

H-Index - 125

eISSN - 1523-5866

pISSN - 1522-8517

DOI - 10.1093/neuonc/not330

Subject(s) - medicine , meningioma , bevacizumab , progression free survival , radiation therapy , oncology , surgery , radiosurgery , temozolomide , chemotherapy

The outcomes of patients with surgery- and radiation-refractory meningiomas treated with medical therapies are poorly defined. Published reports are limited by small patient numbers, selection bias, inclusion of mixed histologic grades and stages of illness, and World Health Organization (WHO) criteria changes. This analysis seeks to define outcome benchmarks for future clinical trial design.

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