Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma | Zendy

Roshan Mahabir | Zendy; Mishie Tanino | Zendy; Aiman Elmansuri | Zendy; Lei Wang | Zendy; Taichi Kimura | Zendy; Tamio Itoh | Zendy; Yusuke Ohba | Zendy; Hiroshi Nishihara | Zendy; Hiroki Shirato | Zendy; Masumi Tsuda | Zendy; Shinya Tanaka | Zendy

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Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma

Author(s) -

Roshan Mahabir,

Mishie Tanino,

Aiman Elmansuri,

Lei Wang,

Taichi Kimura,

Tamio Itoh,

Yusuke Ohba,

Hiroshi Nishihara,

Hiroki Shirato,

Masumi Tsuda,

Shinya Tanaka

Publication year - 2013

Publication title -

neuro-oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.005

H-Index - 125

eISSN - 1523-5866

pISSN - 1522-8517

DOI - 10.1093/neuonc/not239

Subject(s) - glioma , snail , epithelial–mesenchymal transition , mesenchymal stem cell , cancer research , irradiation , transition (genetics) , biology , pathology , medicine , ecology , physics , genetics , gene , nuclear physics

Ionizing irradiation is an effective treatment for malignant glioma (MG); however, a higher rate of recurrence with more aggressive phenotypes is a vital issue. Although epithelial-mesenchymal transition (EMT) is involved in irradiation-induced cancer progression, the role for such phenotypic transition in MG remains unknown.

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