Impact of MACC1 on human malignant glioma progression and patients' unfavorable prognosis | Zendy

Carsten Hagemann | Zendy; Steffen Fuchs | Zendy; CameliaMaria Monoranu | Zendy; Pia Herrmann | Zendy; Janice Smith | Zendy; Tim Hohmann | Zendy; Urszula Grabiec | Zendy; Almuth F. Keßler | Zendy; Faramarz Dehghani | Zendy; Mario Löhr | Zendy; RalfIngo Ernestus | Zendy; Giles H. Vince | Zendy; Ulrike Stein | Zendy

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Impact of MACC1 on human malignant glioma progression and patients' unfavorable prognosis

Author(s) -

Carsten Hagemann,

Steffen Fuchs,

CameliaMaria Monoranu,

Pia Herrmann,

Janice Smith,

Tim Hohmann,

Urszula Grabiec,

Almuth F. Keßler,

Faramarz Dehghani,

Mario Löhr,

RalfIngo Ernestus,

Giles H. Vince,

Ulrike Stein

Publication year - 2013

Publication title -

neuro-oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.005

H-Index - 125

eISSN - 1523-5866

pISSN - 1522-8517

DOI - 10.1093/neuonc/not136

Subject(s) - glioma , oncology , medicine , cancer research

Metastasis-associated in colon cancer 1 (MACC1) has been established as an independent prognostic indicator of metastasis formation and metastasis-free survival for patients with colon cancer and other solid tumors. However, no data are available concerning MACC1 expression in human astrocytic tumors. Glioblastoma multiforme (GBM) is the most prevalent primary brain tumor of adulthood, and due to its invasive and rapid growth, patients have unfavorable prognoses. Although these tumors rarely metastasize, their invasive and migratory behavior is similar to those of metastatic cells of tumors of different origin. Thus, we hypothesized that MACC1 may be involved in progression of human gliomas.

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