Open AccessExpression of CD163 prevents apoptosis through the production of granulocyte colony-stimulating factor in meningioma
Author(s) -
Hiromi Kanno,
Hiroshi Nishihara,
Lei Wang,
Sayaka Yuzawa,
Hiroyuki Kobayashi,
Makoto Tsuda,
Taichi Kimura,
Mishie Tanino,
Shunsuke Terasaka,
Shinya Tanaka
Publication year - 2013
Publication title -
neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/not028
Subject(s) - meningioma , immunohistochemistry , cd163 , pathology , apoptosis , cancer research , biology , reverse transcription polymerase chain reaction , medicine , gene expression , in vitro , gene , macrophage , biochemistry
CD163 is a 130-kDa transmembrane protein expressed in human monocytes and macrophages, and the aberrant expression of CD163 in breast and colorectal cancer associated with patients' poor prognosis was reported. Here, we analyzed the expression of CD163 in meningioma, a common intracranial tumor, and its molecular mechanism in association with meningioma progression.
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