Open AccessIdentifying the mesenchymal molecular subtype of glioblastoma using quantitative volumetric analysis of anatomic magnetic resonance images
Author(s) -
Kourosh M. Naeini,
Whitney B. Pope,
Timothy F. Cloughesy,
Robert J. Harris,
Albert Lai,
Ascia Eskin,
Reshmi Chowdhury,
Heidi Phillips,
Phioanh L. Nghiemphu,
Yalda Behbahanian,
Benjamin M. Ellingson
Publication year - 2013
Publication title -
neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/not008
Subject(s) - fluid attenuated inversion recovery , magnetic resonance imaging , necrosis , pathology , medicine , isocitrate dehydrogenase , glioblastoma , hyperintensity , nuclear medicine , radiology , chemistry , cancer research , enzyme , biochemistry
Subtypes of glioblastoma multiforme (GBM) based on genetic and molecular alterations are thought to cause alterations in anatomic MRI owing to downstream biological changes, such as edema production, blood-brain barrier breakdown, and necrosis. The purpose of the current study was to identify a potential relationship between imaging features and the mesenchymal (MES) GBM subtype, which has the worst patient prognosis.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom