Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways | Zendy

Stella Sun | Zendy; Derek Lee | Zendy; Amy Ho | Zendy; Jenny Kan-Suen Pu | Zendy; X.Q. Zhang | Zendy; Nikki P. Lee | Zendy; Philip J. Day | Zendy; WaiMan Lui | Zendy; C. F. Fung | Zendy; Gkk Leung | Zendy

Open Access

Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways

Author(s) -

Stella Sun,

Derek Lee,

Amy Ho,

Jenny Kan-Suen Pu,

X.Q. Zhang,

Nikki P. Lee,

Philip J. Day,

WaiMan Lui,

C. F. Fung,

Gkk Leung

Publication year - 2013

Publication title -

neuro-oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.005

H-Index - 125

eISSN - 1523-5866

pISSN - 1522-8517

DOI - 10.1093/neuonc/not005

Subject(s) - temozolomide , glioma , cancer research , gene knockdown , apoptosis , in vivo , medicine , unfolded protein response , endoplasmic reticulum , biology , microbiology and biotechnology , biochemistry

Glioblastoma multiforme (GBM), the most aggressive malignant primary brain tumor of the central nervous system, is characterized by a relentless disease recurrence despite continued advancement in surgery, radiotherapy, and chemotherapy. Resistance to temozolomide (TMZ), a standard chemotherapeutic agent for GBM, remains a major challenge. Understanding the mechanisms behind TMZ resistance can direct the development of novel strategies for the prevention, monitoring, and treatment of tumor relapse.

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