Biopsy validation of 18F-DOPA PET and biodistribution in gliomas for neurosurgical planning and radiotherapy target delineation: results of a prospective pilot study | Zendy

D.H. Pafundi | Zendy; Nadia N. Laack | Zendy; Ryan S. Youland | Zendy; Ian F. Parney | Zendy; Val J. Lowe | Zendy; Caterina Giannini | Zendy; Brad Kemp | Zendy; Michael P. Grams | Zendy; James M. Morris | Zendy; Jason M. Hoover | Zendy; Leland Hu | Zendy; Jann N. Sarkaria | Zendy; Debra H. Brinkmann | Zendy

Open Access

Biopsy validation of 18F-DOPA PET and biodistribution in gliomas for neurosurgical planning and radiotherapy target delineation: results of a prospective pilot study

Author(s) -

D.H. Pafundi,

Nadia N. Laack,

Ryan S. Youland,

Ian F. Parney,

Val J. Lowe,

Caterina Giannini,

Brad Kemp,

Michael P. Grams,

James M. Morris,

Jason M. Hoover,

Leland Hu,

Jann N. Sarkaria,

Debra H. Brinkmann

Publication year - 2013

Publication title -

neuro-oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.005

H-Index - 125

eISSN - 1523-5866

pISSN - 1522-8517

DOI - 10.1093/neuonc/not002

Subject(s) - histopathology , medicine , biopsy , glioma , nuclear medicine , radiation therapy , stereotactic biopsy , radiology , biodistribution , pathology , in vivo , microbiology and biotechnology , cancer research , biology

Delineation of glioma extent for surgical or radiotherapy planning is routinely based on MRI. There is increasing awareness that contrast enhancement on T1-weighted images (T1-CE) may not reflect the entire extent of disease. The amino acid tracer (18)F-DOPA (3,4-dihydroxy-6-[18F] fluoro-l-phenylalanine) has a high tumor-to-background signal and high sensitivity for glioma imaging. This study compares (18)F-DOPA PET against conventional MRI for neurosurgical biopsy targeting, resection planning, and radiotherapy target volume delineation.

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