Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging | Zendy

Jae Mo Park | Zendy; Lawrence D. Recht | Zendy; Sonal Josan | Zendy; Milton Merchant | Zendy; Tae-Oh Jang | Zendy; YiFen Yen | Zendy; Ralph E. Hurd | Zendy; Daniel M. Spielman | Zendy; Dirk Mayer | Zendy

Open Access

Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging

Author(s) -

Jae Mo Park,

Lawrence D. Recht,

Sonal Josan,

Milton Merchant,

Tae-Oh Jang,

YiFen Yen,

Ralph E. Hurd,

Daniel M. Spielman,

Dirk Mayer

Publication year - 2013

Publication title -

neuro-oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.005

H-Index - 125

eISSN - 1523-5866

pISSN - 1522-8517

DOI - 10.1093/neuonc/nos319

Subject(s) - bicarbonate , pyruvate dehydrogenase complex , in vivo , glioma , chemistry , glycolysis , metabolite , anaerobic glycolysis , biochemistry , metabolism , biology , cancer research , enzyme , microbiology and biotechnology , organic chemistry

The metabolic phenotype that derives disproportionate energy via glycolysis in solid tumors, including glioma, leads to elevated lactate labeling in metabolic imaging using hyperpolarized [1-(13)C]pyruvate. Although the pyruvate dehydrogenase (PDH)-mediated flux from pyruvate to acetyl coenzyme A can be indirectly measured through the detection of carbon-13 ((13)C)-labeled bicarbonate, it has proven difficult to visualize (13)C-bicarbonate at high enough levels from injected [1-(13)C]pyruvate for quantitative analysis in brain. The aim of this study is to improve the detection of (13)C-labeled metabolites, in particular bicarbonate, in glioma and normal brain in vivo and to measure the metabolic response to dichloroacetate, which upregulates PDH activity.

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