Open AccessWnt/β-catenin signaling is a key downstream mediator of MET signaling in glioblastoma stem cells
Author(s) -
Kang Ho Kim,
Ho Jun Seol,
Eun Hee Kim,
Jinguen Rheey,
Hyun Jin Jin,
Yeri Lee,
Kyeung Min Joo,
Jeongwu Lee,
DoHyun Nam
Publication year - 2012
Publication title -
neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/nos299
Subject(s) - wnt signaling pathway , cancer research , biology , signal transduction , stem cell , effector , ectopic expression , cancer stem cell , autocrine signalling , beta catenin , microbiology and biotechnology , cell culture , genetics
Glioblastoma (GBM) is the most lethal and common type of primary brain tumor. Recent evidence suggests that a subpopulation of GBM cells (glioblastoma stem cells [GSCs]) is critical for tumor progression, invasion, and therapeutic resistance. We and others have demonstrated that MET, a receptor tyrosine kinase, positively regulates the stemness phenotype and radioresistance of GSCs. Here, we interrogated the downstream effector pathways of MET signaling in GSCs.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom