MiR-218 sensitizes glioma cells to apoptosis and inhibits tumorigenicity by regulating ECOP-mediated suppression of NF-κB activity | Zendy

Hongping Xia | Zendy; Yukui Yan | Zendy; Minghua Hu | Zendy; Yaxian Wang | Zendy; Yongsheng Wang | Zendy; Yi Dai | Zendy; Jianming Chen | Zendy; Guangfu Di | Zendy; Xiaobing Chen | Zendy; Xiaochun Jiang | Zendy

Open Access

MiR-218 sensitizes glioma cells to apoptosis and inhibits tumorigenicity by regulating ECOP-mediated suppression of NF-κB activity

Author(s) -

Hongping Xia,

Yukui Yan,

Minghua Hu,

Yaxian Wang,

Yongsheng Wang,

Yi Dai,

Jianming Chen,

Guangfu Di,

Xiaobing Chen,

Xiaochun Jiang

Publication year - 2012

Publication title -

neuro-oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.005

H-Index - 125

eISSN - 1523-5866

pISSN - 1522-8517

DOI - 10.1093/neuonc/nos296

Subject(s) - glioma , apoptosis , ectopic expression , cancer research , downregulation and upregulation , cell growth , biology , microrna , viability assay , transfection , terminal deoxynucleotidyl transferase , microbiology and biotechnology , chemistry , cell culture , tunel assay , biochemistry , gene , genetics

Malignant gliomas are the most common and deadly primary brain tumors in adults. Increasing evidence has indicated that microRNAs (miRNAs) have an influence on the regulation of apoptotic cell signaling. Downregulation of miRNA 218 (miR-218) has been indicated in human glioma specimens. Here, we investigate the function of miR-218 in apoptosis and tumor growth of glioma cells.

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