High -catenin/Tcf-4 activity confers glioma progression via direct regulation of AKT2 gene expression | Zendy

Jian-Nan Zhang | Zendy; Kai Huang | Zendy; Zhu Shi | Zendy; Jian Zou | Zendy; Yingwei Wang | Zendy; Zhanjun Jia | Zendy; Jianhua Zhang | Zendy; Lei Han | Zendy; Xin Yue | Zendy; Ning Liu | Zendy; Tao Jiang | Zendy; Yibing You | Zendy; Peng Pu | Zendy; Chunsheng Kang | Zendy

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High -catenin/Tcf-4 activity confers glioma progression via direct regulation of AKT2 gene expression

Author(s) -

Jian-Nan Zhang,

Kai Huang,

Zhu Shi,

Jian Zou,

Yingwei Wang,

Zhanjun Jia,

Jianhua Zhang,

Lei Han,

Xin Yue,

Ning Liu,

Tao Jiang,

Yibing You,

Peng Pu,

Chunsheng Kang

Publication year - 2011

Publication title -

neuro-oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.005

H-Index - 125

eISSN - 1523-5866

pISSN - 1522-8517

DOI - 10.1093/neuonc/nor034

Subject(s) - carcinogenesis , akt2 , catenin , cancer research , chromatin immunoprecipitation , glioma , tumor progression , beta catenin , cell growth , signal transduction , biology , in vivo , chemistry , microbiology and biotechnology , gene expression , gene , wnt signaling pathway , promoter , akt1 , protein kinase b , genetics

Recent data suggest that the β-catenin/Tcf-4 signaling pathway plays an important role in human cancer tumorigenesis. However, the mechanism of β-catenin/Tcf-4 signaling in tumorigenesis is poorly understood. In this study, we show that Tcf-4 protein levels were significantly elevated in high-grade gliomas in comparison with low-grade gliomas and that Tcf-4 levels correlated with levels of AKT2. Reduction of β-catenin/Tcf-4 activity inhibited glioma cell proliferation and invasion in vitro and tumor growth in vivo. This effect of β-catenin/Tcf-4 activity was mediated by AKT2, and in vivo binding of β-catenin/Tcf-4 to the AKT2 promoter was validated using the chromatin immunoprecipitation assay and luciferase reporter assays. Taken together, we have demonstrated that Tcf-4 is associated with glioma progression and that AKT2 is a new member of the genes that are regulated by β-catenin/Tcf-4.

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