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Interferon beta is widely used for the treatment of relapsing and remitting multiple sclerosis. Renal side effects including nephrotic syndrome have been increasingly described with interferon beta treatment. We describe an illustrative case of a patient who developed severe nephrotic syndrome due to minimal change disease in association with interferon beta therapy and showed partial remission following cessation of interferon beta and treatment with corticosteroids.

Minimal change disease with interferon-beta therapy for relapsing remitting multiple sclerosis