Albumin downregulates Klotho in tubular cells | Zendy

Beatriz FernándezFernández | Zendy; María C. Izquierdo | Zendy; Lara ValiñoRivas | Zendy; Dimitra Nastou | Zendy; Ana B. Sanz | Zendy; Alberto Ortíz | Zendy; María Dolores Sánchez-Niño | Zendy

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Albumin downregulates Klotho in tubular cells

Author(s) -

Beatriz FernándezFernández,

María C. Izquierdo,

Lara ValiñoRivas,

Dimitra Nastou,

Ana B. Sanz,

Alberto Ortíz,

María Dolores Sánchez-Niño

Publication year - 2017

Publication title -

nephrology dialysis transplantation

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfx376

Subject(s) - klotho , medicine , albumin , endocrinology , pathology , kidney

Kidney tubular cells are the main sources of Klotho, a protein with phosphaturic action. Genetic Klotho deficiency causes premature cardiovascular aging in mice. Human chronic kidney disease (CKD) is characterized by acquired Klotho deficiency. Despite the lack of uremic toxin accumulation, Category G1 CKD [(normal glomerular filtration rate (GFR)] is already associated with decreased Klotho and with premature cardiovascular aging.

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